Genomic Relativity
Genomic relativity is a developing way to describe genomes without treating any one reference assembly as the biological center. A genome is the physical nucleic acid itself, while a genome assembly is a representation reconstructed from sequencing reads. We are exploring how to describe genomic positions and variants without making them products of a single reference.
Essays
These essays begin with the practical consequences in clinical genome reports, then examine the deeper assumption that genomic meaning needs a privileged coordinate system at all. As we develop the theory, more essays will come.
What Your Genome Report Doesn't Say
How clinical reports turn a person's DNA into differences from a reference, what that representation misses, and what a personal assembly could change.
Some Guy From Buffalo
How human genomics inherited a center and why replacing one reference with a better one does not remove the deeper assumption.