Genomic Relativity
Genomic relativity is a developing way to describe genomes without treating any one reference assembly as the biological center. A genome is the physical nucleic acid itself, while a genome assembly is a representation reconstructed from sequencing reads. We are exploring how to describe genomic positions and variants without making them products of a single reference.
Essays
These essays begin with the practical consequences in clinical genome reports, then examine the deeper assumption that genomic meaning needs a privileged coordinate system at all. As we develop the theory, more essays will come.
What Your Genome Report Doesn't Say
How clinical reports turn a person's DNA into differences from a reference, what that representation misses, and what a personal assembly could change.
Some Guy From Buffalo
How human genomics inherited a center and why replacing one reference with a better one does not remove the deeper assumption.
Relative To What
Why genomics remains anchored to privileged coordinates, and how rebuilding from physical molecules could make references bookkeeping rather than foundation.